Process of making dialkyl-malonyl-urea.



FRITZ MAYER, OF MAYENCE, GERMANY.

PROCESS OF MAKING DIALKYL-MALONYL-UREA.

Specification of Letters Patent.

Patented Nov. '7, 1905.

Application filed April 15, 1905. Serial No. 255,822.

To all whom it may concern.-

Be it known that I, FRITZ MAYER, a subject of the German Emperor,residing at Mayence, Germany, have invented certain new and usefulImprovements in Processes of Preparing Dialkyl-Malonyl-Urea, of whichthe following is a specification.

Heretofore it has been discovered that diethylmalonylurea has a greatsleep-producing eifect, whereas, forinstance, dipropolmalonylguanidin iswithout such effect, (T/Lerapie (Zer Gegemoart, 1903. page 98, &c.) Fromthis it has been concluded that the CO group, which is present in theurea molecule, is necessary to obtain said hypnotic effect. I have madethe attempt to produce, if possible, even a stronger sleep-producingdrug containing two CO groups by reaction between biuret anddiethylmalonyl chlorid, according to the following equation:

This attempt resulted in the unexpected and surprising fact that thereaction took the following course:

' in the above description is ethyl and although the halide that I havementioned is chlorid, I do not wish to be understood as limiting myselfspecifically to either the ethyl or the chlorid, unless so expressed inthe claims.

The term biuret is used in the appended claims in its broad sense and isnot to be understood as limited to the specific biuret of the preciseformula above set forth.

Having thus described my invention, Iclaim as new and desire to secureby Letters Patent- 1. The process of preparingdialkylmalonylurea whichconsists in causing a chemical reaction between a biuret and adialkylmalonylhalide.

2. The process of preparingdialkylmalonylurea which consists in causinga chemical 'reaction between a biuret and a dialkylmalonyl chlorid.

3. The process of preparing diethylmalonylurea which consists in causinga chemical reaction between a biuret and diethylmalonyl chlorid.

In testimony whereofI have hereunto signed my name in the presence oftwo subscribing witnesses.

IOO

FRITZ MAYER.

Witnesses WALTER HAUSING, WALTER SOHUMANN.

